BDBM643753 US20240002393, Example 106::[(4R)-7-chloro-6-(2,6-difluorophenyl)-1-methyl-8-(trifluoromethyl)-4H-[1,2,4]triazlo[4,3-a][1,4]benzodiazepin-4-yl]methanol

SMILES Cc1nnc2[C@H](CO)N=C(c3c(F)cccc3F)c3c(Cl)c(ccc3-n12)C(F)(F)F

InChI Key InChIKey=GQDLMDJYFOAJEL-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 643753   

LigandPNGBDBM643753([(4R)-7-chloro-6-(2,6-difluorophenyl)-1-methyl-8-(...)
Affinity DataKi:  4.30nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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Date in BDB:
2/28/2024
Entry Details
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LigandPNGBDBM643753([(4R)-7-chloro-6-(2,6-difluorophenyl)-1-methyl-8-(...)
Affinity DataKi:  71.3nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
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LigandPNGBDBM643753([(4R)-7-chloro-6-(2,6-difluorophenyl)-1-methyl-8-(...)
Affinity DataKi:  7.64E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
Go to US Patent