BDBM643749 US20240002393, Example 101::[(4R)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]methanol

SMILES Cc1nnc2[C@H](CO)N=C(c3c(F)cccc3F)c3c(Cl)c(Br)ccc3-n12

InChI Key InChIKey=RQNGTQFJWSNXHS-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 643749   

LigandPNGBDBM643749([(4R)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-1-me...)
Affinity DataKi:  1nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
Go to US Patent

LigandPNGBDBM643749([(4R)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-1-me...)
Affinity DataKi:  14.3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
Go to US Patent

LigandPNGBDBM643749([(4R)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-1-me...)
Affinity DataKi:  26.4nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
Go to US Patent

LigandPNGBDBM643749([(4R)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-1-me...)
Affinity DataKi:  495nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
Go to US Patent