BDBM643738 (4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-4-methyl-1-(6-methylpyridazin-3-yl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine::US20240002393, Example 88

SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Br)c(Cl)ccc2-n2c1nnc2-c1ccc(C)nn1

InChI Key InChIKey=RVHBYZHFOCCONE-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 643738   

LigandPNGBDBM643738((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-4-met...)
Affinity DataKi:  3.60nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
Go to US Patent

LigandPNGBDBM643738((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-4-met...)
Affinity DataKi:  10.9nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
Go to US Patent

LigandPNGBDBM643738((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-4-met...)
Affinity DataKi:  34.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
Go to US Patent

LigandPNGBDBM643738((4S)-7-bromo-8-chloro-6-(2,6-difluorophenyl)-4-met...)
Affinity DataKi:  1.45E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
Go to US Patent