BDBM643728 (4S)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-1,4-dimethyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine::US20240002393, Example 75

SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(Br)ccc2-n2c(C)nnc12

InChI Key InChIKey=UDTZRZLWBNBNCX-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 643728   

LigandPNGBDBM643728((4S)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-1,4-d...)
Affinity DataKi:  0.800nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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Date in BDB:
2/28/2024
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LigandPNGBDBM643728((4S)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-1,4-d...)
Affinity DataKi:  5.30nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
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LigandPNGBDBM643728((4S)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-1,4-d...)
Affinity DataKi:  8.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
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LigandPNGBDBM643728((4S)-8-bromo-7-chloro-6-(2,6-difluorophenyl)-1,4-d...)
Affinity DataKi:  202nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
Go to US Patent