BDBM642788 US11857552, Compound APPAMP-002

SMILES O[C@H]1CNCC[C@@H]1CNc1cc(NCc2ccccc2)n2ncc(C3CC3)c2n1

InChI Key InChIKey=ATGAGBNTLIIJJW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 642788   

TargetCyclin-dependent kinase 2(Human)
Carrick Therapeutics

US Patent
LigandPNGBDBM642788(US11857552, Compound APPAMP-002)
Affinity DataIC50: 770nMAssay Description:CDK2 IC50 Materials and solutions:HEPES (Sigma, H3375).Sodium orthovanadate (Sigma, 450243).DTT (Sigma).MgCl2 (Sigma, M1028).PEG-20000 (Sigma, 95172)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 7(Human)
Carrick Therapeutics

US Patent
LigandPNGBDBM642788(US11857552, Compound APPAMP-002)
Affinity DataIC50: 33nMAssay Description:CDK7 IC50 Materials and Solutions:In addition to those mentioned above for Method 1:CDK7/cycH/MAT1 (ProQinase, 0366-0360-4).MnCl2 (Sigma, M1787).CDKt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 9(Human)
Carrick Therapeutics

US Patent
LigandPNGBDBM642788(US11857552, Compound APPAMP-002)
Affinity DataIC50: 210nMAssay Description:CDK9 IC50 Materials and Solutions:In addition to those mentioned above for Method 1:Human CDK9/cycK (Promega, V4104).CDKtide (SignalChem, C06-58).Ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 7(Human)
Carrick Therapeutics

US Patent
LigandPNGBDBM642788(US11857552, Compound APPAMP-002)
Affinity DataIC50: 33nMAssay Description:CDK7 IC50 Materials and Solutions:In addition to those mentioned above for Method 1:CDK7/cycH/MAT1 (ProQinase, 0366-0360-4).MnCl2 (Sigma, M1787).CDKt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2(Human)
Carrick Therapeutics

US Patent
LigandPNGBDBM642788(US11857552, Compound APPAMP-002)
Affinity DataIC50: 770nMAssay Description:CDK2 IC50 Materials and solutions:HEPES (Sigma, H3375).Sodium orthovanadate (Sigma, 450243).DTT (Sigma).MgCl2 (Sigma, M1028).PEG-20000 (Sigma, 95172)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2024
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 7(Human)
Carrick Therapeutics

US Patent
LigandPNGBDBM642788(US11857552, Compound APPAMP-002)
Affinity DataIC50: 33nMAssay Description:CDK7 IC50 Materials and Solutions:In addition to those mentioned above for Method 1:CDK7/cycH/MAT1 (ProQinase, 0366-0360-4).MnCl2 (Sigma, M1787).CDKt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2024
Entry Details
Go to US Patent