BDBM642608 (R)-4,4-difluoro-N-(3-(2- ((3-methoxy-1-meth- yl-1H-pyrazol-4-yl)ami- no)-5-methylpyrimidin- 4-yl)-1H-indol-7-yl)-1- ((R)-tetrahydrofuran-3- yl)pyrrolidine-2-carbo- xamide::US20230416237, Example 34::US20230416237, Example 35

SMILES COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)C3CC(F)(F)CN3C3CCOC3)cccc12

InChI Key InChIKey=UOIJCKCMXOESCE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 642608   

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642608(US20230416237, Example 35 | (R)-4,4-difluoro-N-(3-...)
Affinity DataIC50: 161nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642608(US20230416237, Example 35 | (R)-4,4-difluoro-N-(3-...)
Affinity DataIC50: 2.51E+3nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642608(US20230416237, Example 35 | (R)-4,4-difluoro-N-(3-...)
Affinity DataIC50: 115nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642608(US20230416237, Example 35 | (R)-4,4-difluoro-N-(3-...)
Affinity DataIC50: 1.89E+3nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent