BDBM642599 (2R,3'R)-4,4-difluoro-N- (3-(5-fluoro-2-((3-meth- oxy-1-methyl-1H-pyra- zol-4-yl)amino)pyrimi- din-4-yl)-1H-indol-7-yl)- 1'-methyl-[1,3'-bipyrro- lidine]-2-carboxamide::US20230416237, Example 26

SMILES COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)C3CC(F)(F)CN3C3CCN(C)C3)cccc12

InChI Key InChIKey=LLWSBODAMDLYJL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 642599   

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642599((2R,3'R)-4,4-difluoro-N- (3-(5-fluoro-2-((3-meth- ...)
Affinity DataIC50: 48nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642599((2R,3'R)-4,4-difluoro-N- (3-(5-fluoro-2-((3-meth- ...)
Affinity DataIC50: 5.49E+3nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent