BDBM642594 US20230416237, Example 21

SMILES COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@H]3C[C@H](F)CN3[C@H]3CCN(C)C3)cccc12

InChI Key InChIKey=MDDCFXBVSPHUAV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 642594   

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642594(US20230416237, Example 21)
Affinity DataIC50: 262nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642594(US20230416237, Example 21)
Affinity DataIC50: 3.00E+4nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent