BDBM642589 (R)-4,4-difluoro- N-(3-(2-((3-meth- oxy-1-methyl-1H- pyrazol-4-yl)ami- no)-5-methylpyri- midin-4-yl)-1H- indol-7-yl)-1-(1- methylpiperidin- 4-yl)pyrrolidine- 2-carboxamide::US20230416237, Example 16

SMILES COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)C3CC(F)(F)CN3C3CCN(C)CC3)cccc12

InChI Key InChIKey=ZBLZRAFXZWLUSC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 642589   

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642589((R)-4,4-difluoro- N-(3-(2-((3-meth- oxy-1-methyl-1...)
Affinity DataIC50: 40nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642589((R)-4,4-difluoro- N-(3-(2-((3-meth- oxy-1-methyl-1...)
Affinity DataIC50: 3.34E+3nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent