BDBM642586 (2R,4S)-4-methoxy- N-(3-(2-((3-meth- oxy-1-methyl- 1H-pyrazol-4-yl) amino)-5-methyl- pyrimidin-4-yl)- 1H-indol-7-yl)-1- (1-methylpiperi- din-4-yl)pyrrolidine- 2-carboxamide::US20230416237, Example 13

SMILES CO[C@H]1CC(N(C1)C1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C

InChI Key InChIKey=RPVBQNTXUHONHD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 642586   

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642586((2R,4S)-4-methoxy- N-(3-(2-((3-meth- oxy-1-methyl-...)
Affinity DataIC50: 101nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642586((2R,4S)-4-methoxy- N-(3-(2-((3-meth- oxy-1-methyl-...)
Affinity DataIC50: 1.45E+4nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent