BDBM642581 (2R,4R)-N-(3-(5- fluoro-2-((3-meth- oxy-1-methyl-1H- pyrazol-4-yl)a- mino)pyrimidin- 4-yl)-1H-indol-7- yl)-4-methoxy-1- (piperidin-4-yl) pyrrolidine-2-car- boxamide::US20230416237, Example 8

SMILES CO[C@@H]1CC(N(C1)C1CCNCC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F

InChI Key InChIKey=BCSRCGGIOYAABA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 642581   

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642581((2R,4R)-N-(3-(5- fluoro-2-((3-meth- oxy-1-methyl-1...)
Affinity DataIC50: 1.17E+3nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642581((2R,4R)-N-(3-(5- fluoro-2-((3-meth- oxy-1-methyl-1...)
Affinity DataIC50: 1.05E+4nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent