BDBM642580 (2R,4R)-4-fluoro- N-(3-(5-fluoro-2- ((3-methoxy-1- methyl-1H-pyrazol- 4-yl)amino)py- rimidin-4-yl)-1H- indol-7-yl)-1-(pi- peridin-4-yl)pyrro- lidine-2-carbox- amide::US20230416237, Example 7

SMILES COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)C3C[C@@H](F)CN3C3CCNCC3)cccc12

InChI Key InChIKey=SLMFNNALXOAPBQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 642580   

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642580((2R,4R)-4-fluoro- N-(3-(5-fluoro-2- ((3-methoxy-1-...)
Affinity DataIC50: 152nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642580((2R,4R)-4-fluoro- N-(3-(5-fluoro-2- ((3-methoxy-1-...)
Affinity DataIC50: 4.41E+3nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent