BDBM642579 (2R,4S)-4-fluoro- N-(3-(5-fluoro-2- ((3-methoxy-1-meth- yl-1H-pyrazol- 4-yl)amino)pyri- midin-4-yl)-1H-in- dol-7-yl)-1-(piper- idin-4-yl)pyrro- lidine-2-carboxa- mide::US20230416237, Example 6

SMILES COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)C3C[C@H](F)CN3C3CCNCC3)cccc12

InChI Key InChIKey=SLMFNNALXOAPBQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 642579   

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642579((2R,4S)-4-fluoro- N-(3-(5-fluoro-2- ((3-methoxy-1-...)
Affinity DataIC50: 68nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642579((2R,4S)-4-fluoro- N-(3-(5-fluoro-2- ((3-methoxy-1-...)
Affinity DataIC50: 4.00E+3nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent