BDBM642577 (S)-N-(3-(5-chloro- 2-((3-methoxy-1-meth- yl-1H-pyrazol-4- yl)amino)pyrimidin- 4-yl)-1H-indol-7- yl)-1-(methanesulfo- nyl)pyrrolidine-2- carboxamide::US20230416237, Example 4

SMILES COc1nn(C)cc1Nc1ncc(Cl)c(n1)-c1c[nH]c2c(NC(=O)C3CCCN3S(C)(=O)=O)cccc12

InChI Key InChIKey=RWMNUIPGIWWKCR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 642577   

TargetTyrosine-protein kinase JAK1(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642577((S)-N-(3-(5-chloro- 2-((3-methoxy-1-meth- yl-1H-py...)
Affinity DataIC50: 53nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Artivila (Shenzhen) Innovation Center

US Patent
LigandPNGBDBM642577((S)-N-(3-(5-chloro- 2-((3-methoxy-1-meth- yl-1H-py...)
Affinity DataIC50: 652nMAssay Description:The inhibitory activity (IC50) of the amide compound for JAK1 and JAK2 under 1 mM ATP was measured by a mobility shift assay method. JAK1 was purchas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
Go to US Patent