BDBM642373 N-(((2S,5R)-5-((3-(4-(2,6-difluorophenoxy)-2-fluorobenzoyl)-5-fluoro-JH-pyrrolo[2,3-b]pyridin-4-yl)amino)tetrahydro-2H-pyran-2-yl)methyl)methanesulfonamide ::US20230406856, Example 1

SMILES CS(=O)(=O)NC[C@@H]1CC[C@H](CO1)Nc1c(F)cnc2[nH]cc(C(=O)c3ccc(Oc4c(F)cccc4F)cc3F)c12

InChI Key InChIKey=VWXAKKVHABCTNK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 642373   

TargetTyrosine-protein kinase BTK [C481S](Human)
Fochon Biosciences

US Patent
LigandPNGBDBM642373(N-(((2S,5R)-5-((3-(4-(2,6-difluorophenoxy)-2-fluor...)
Affinity DataIC50: 1.5nMAssay Description:The kinase activity of BTK (C481S) was assayed at Reaction Biology Corporation. The substrate in the BTK (C481S) reaction, pEY (poly[Glu:Tyr] (4:1)) ...More data for this Ligand-Target Pair
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Date in BDB:
2/12/2024
Entry Details
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