BDBM6418 N-(3-chlorophenyl)-6-(5-{[2-(dimethylamino)ethyl]amino}pyridin-3-yl)pyrazin-2-amine::N-{5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-pyridin-3-yl}-N ,N -dimethyl-ethane-1,2-diamine::Pyrazine-Pyridine Biheteroaryl 41

SMILES CN(C)CCNc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1

InChI Key InChIKey=XTEWWTLBXKFYCF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 6418   

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6418(N-{5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-pyrid...)
Affinity DataIC50: 1.00E+4nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2005
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Rat)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6418(N-{5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-pyrid...)
Affinity DataIC50: 105nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2005
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6418(N-{5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-pyrid...)
Affinity DataIC50: 1.00E+4nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2005
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta [7-25](Rabbit)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6418(N-{5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-pyrid...)
Affinity DataIC50: 1.00E+4nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6418(N-{5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-pyrid...)
Affinity DataIC50: 1.40E+3nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Johnson & Johnson Pharmaceutical

LigandPNGBDBM6418(N-{5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-pyrid...)
Affinity DataIC50: 1.00E+4nMAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2005
Entry Details Article
PubMed