BDBM640460 US20230399319, Example 2-004

SMILES Cc1ccc(cc1Nc2nc(co2)C(=O)NS(=O)(=O)N3CCCOCC3)C(F)(F)F

InChI Key InChIKey=AXBUEIBPZRUIGE-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 640460   

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

US Patent
LigandPNGBDBM640460(US20230399319, Example 2-004)
Affinity DataIC50: 21nMAssay Description:The NLRP3 inflammasome inhibitory activity of test compounds were evaluated CM the basis of the inhibitory activity of the IL-1β, production in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2024
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

US Patent
LigandPNGBDBM640460(US20230399319, Example 2-004)
Affinity DataIC50: 21nMAssay Description:Inhibition of NLRP3 in LPS/nigericin-induced human THP-1 cells assessed as inhibition of IL-1beta production pretreated with LPS for 3 hrs followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

US Patent
LigandPNGBDBM640460(US20230399319, Example 2-004)
Affinity DataIC50: 570nMAssay Description:Inhibition of NLRP3 in human whole blood assessed as inhibition of IL-1beta production pretreated with LPS for 3 hrs followed by incubation with comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNLR family CARD domain-containing protein 4(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM640460(US20230399319, Example 2-004)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of NLRC4 (unknown origin) in PMA-differentiated human THP-1 cells assessed as inhibition of IL-1 beta production pretreated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed