BDBM640375 Preparation of N-(3-((4-amino-7-ethyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethynyl)-4-methylphenyl)-3-(trifluoromethyl)benzamide ::US11840535, Example 17

SMILES CCn1cc(C#Cc2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)c2c(N)ncnc12

InChI Key InChIKey=HQDWFEUKAIUUKI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 640375   

TargetTyrosine-protein kinase ABL1(Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM640375(Preparation of N-(3-((4-amino-7-ethyl-7H-pyrrolo[2...)
Affinity DataIC50: 5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2024
Entry Details
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TargetTyrosine-protein kinase ABL1 [T315I](Human)
Shenzhen Targetrx

US Patent
LigandPNGBDBM640375(Preparation of N-(3-((4-amino-7-ethyl-7H-pyrrolo[2...)
Affinity DataIC50: 5nMAssay Description:Specific Assay Method:Compound formulation: The test compounds were dissolved in DMSO to prepare a 20 mM stock solution. Before use, the compounds we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2024
Entry Details
Go to US Patent