BDBM639341 2-(1-Methyl-1H-imidazol-5-yl)ethyl 3-[(5-chlorothiophene-2-carbonyl)amino]-N-[2-ethyl-3-(2-oxopyrrolidin-1-yl)benzene-1-sulfonyl]-S-alaninate hydrochloride::US20230391761, Reference 9

SMILES CCc1c(cccc1S(=O)(=O)N[C@@H](CNC(=O)c1ccc(Cl)s1)C(=O)OCCc1cncn1C)N1CCCC1=O

InChI Key InChIKey=KBNWFXRFMYBDPZ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 639341   

TargetCoagulation factor X(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639341(2-(1-Methyl-1H-imidazol-5-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 0.890nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
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TargetProthrombin(Human)
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US Patent
LigandPNGBDBM639341(2-(1-Methyl-1H-imidazol-5-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 0.830nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
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TargetCoagulation factor XI(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639341(2-(1-Methyl-1H-imidazol-5-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 7.20E+3nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
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TargetSerine protease 1(Human)
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US Patent
LigandPNGBDBM639341(2-(1-Methyl-1H-imidazol-5-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 1.50E+3nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
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TargetPlasminogen(Human)
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US Patent
LigandPNGBDBM639341(2-(1-Methyl-1H-imidazol-5-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 1.50E+4nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
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TargetTissue-type plasminogen activator(Human)
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US Patent
LigandPNGBDBM639341(2-(1-Methyl-1H-imidazol-5-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 7.90E+3nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
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TargetKallikrein-1(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639341(2-(1-Methyl-1H-imidazol-5-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 260nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
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TargetCytochrome P450 3A4(Human)
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US Patent
LigandPNGBDBM639341(2-(1-Methyl-1H-imidazol-5-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 370nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
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TargetCytochrome P450 1A2(Human)
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US Patent
LigandPNGBDBM639341(2-(1-Methyl-1H-imidazol-5-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 2.00E+4nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
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TargetCytochrome P450 2C8(Human)
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US Patent
LigandPNGBDBM639341(2-(1-Methyl-1H-imidazol-5-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 340nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
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TargetCytochrome P450 2C9(Human)
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US Patent
LigandPNGBDBM639341(2-(1-Methyl-1H-imidazol-5-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 2.32E+3nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
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TargetCytochrome P450 2D6(Human)
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US Patent
LigandPNGBDBM639341(2-(1-Methyl-1H-imidazol-5-yl)ethyl 3-[(5-chlorothi...)
Affinity DataIC50: 1.66E+3nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
Go to US Patent