BDBM639339 Methyl 3-[(5-chlorothiophene-2-carbonyl)amino]-N-{2-ethyl-3-[(3R)-3-hydroxy-2-oxopyrrolidin-1-yl]benzene-1-sulfonyl}-S-alaninate::US20230391761, Reference 7

SMILES CCc1c(cccc1S(=O)(=O)N[C@@H](CNC(=O)c1ccc(Cl)s1)C(=O)OC)N1CC[C@@H](O)C1=O

InChI Key InChIKey=JRJYGGVSLMZUHU-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 639339   

TargetCoagulation factor X(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639339(Methyl 3-[(5-chlorothiophene-2-carbonyl)amino]-N-{...)
Affinity DataIC50: 0.760nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
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TargetProthrombin(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639339(Methyl 3-[(5-chlorothiophene-2-carbonyl)amino]-N-{...)
Affinity DataIC50: 52nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639339(Methyl 3-[(5-chlorothiophene-2-carbonyl)amino]-N-{...)
Affinity DataIC50: 4.70E+4nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
Go to US Patent

TargetSerine protease 1(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639339(Methyl 3-[(5-chlorothiophene-2-carbonyl)amino]-N-{...)
Affinity DataIC50: 1.50E+4nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
Go to US Patent

TargetPlasminogen(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639339(Methyl 3-[(5-chlorothiophene-2-carbonyl)amino]-N-{...)
Affinity DataIC50: 5.00E+4nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
Go to US Patent

TargetTissue-type plasminogen activator(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639339(Methyl 3-[(5-chlorothiophene-2-carbonyl)amino]-N-{...)
Affinity DataIC50: 790nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
Go to US Patent

TargetKallikrein-1(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM639339(Methyl 3-[(5-chlorothiophene-2-carbonyl)amino]-N-{...)
Affinity DataIC50: 1.40E+3nMAssay Description:Determination of the Selectivity To demonstrate the selectivity of the substances with respect to thrombin and factor Xa inhibition, the test substan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
Go to US Patent