BDBM638393 Synthesis of (S)-10-((dimethylamino)methyl)-4-ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl 4-(6-((4-((8S,11R,13S,14S,17R)-17-acetoxy-17-acetyl-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-11-yl)phenyl)(methyl)amino)hexyl)piperazine-1-carboxylate ::US11834458, Example 5

SMILES CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(OC(=O)N5CCN(CCCCCCN(C)c6ccc(cc6)[C@H]6C[C@@]7(C)[C@@H](CC[C@]7(OC(C)=O)C(C)=O)[C@@H]7CCC8=CC(=O)CCC8=C67)CC5)c(CN(C)C)c4cc3Cn1c2=O

InChI Key InChIKey=DFGICJHUDMUNQT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 638393   

TargetAndrogen receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638393(US11834458, Example 5 | Synthesis of (S)-10-((dime...)
Affinity DataIC50: 255nMAssay Description:To assess AR binding, test compound (top dose 10 μM, 4 fold serial dilution, 8 point dose response) and control (progesterone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
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TargetGlucocorticoid receptor(Human)
Nuvation Bio

US Patent
LigandPNGBDBM638393(US11834458, Example 5 | Synthesis of (S)-10-((dime...)
Affinity DataIC50: 10nMAssay Description:To assess GR binding, test compound (top dose 1 μM, 4 fold serial dilution, 8 point dose response) and control (dexamethasone) were transferred ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
Go to US Patent