BDBM638297 US11834453, Example 400

SMILES Cc1cc(Nc2ncnc3cnc(nc23)N2CC[C@H](C2)C(F)F)ccc1Oc1ccn2ncnc2c1

InChI Key InChIKey=OWCMACCXIILWNZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 638297   

LigandPNGBDBM638297(US11834453, Example 400)
Affinity DataIC50: 8.70nMAssay Description:This synthesized DNA fragment was subsequently cloned into the baculovirus transfer vector, pAcSG2, between the NcoI and NotI sites. The resulting pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
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TargetReceptor tyrosine-protein kinase erbB-2(Human)
Array Biopharma

US Patent
LigandPNGBDBM638297(US11834453, Example 400)
Affinity DataIC50: 40.7nMAssay Description:The kinases were incubated with 250 nM TK-substrate biotin (CisBio, part of cat #62TK0PEC) at 1 mM ATP along with test compounds in a buffer consisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
Go to US Patent