BDBM638083 US11834453, Example 186

SMILES CN([C@H]1C[C@H](O)C1)c1ncc2ncnc(Nc3ccc(Oc4ccc5n(C)cnc5c4)c(C)c3)c2n1

InChI Key InChIKey=KQZDEFFWZHRWER-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 638083   

LigandPNGBDBM638083(US11834453, Example 186)
Affinity DataIC50: 5.70nMAssay Description:This synthesized DNA fragment was subsequently cloned into the baculovirus transfer vector, pAcSG2, between the NcoI and NotI sites. The resulting pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Array Biopharma

US Patent
LigandPNGBDBM638083(US11834453, Example 186)
Affinity DataIC50: 3.70nMAssay Description:The kinases were incubated with 250 nM TK-substrate biotin (CisBio, part of cat #62TK0PEC) at 1 mM ATP along with test compounds in a buffer consisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
Go to US Patent