BDBM637899 US11834453, Example 5

SMILES Cc1onc2cc(Oc3ccc(Nc4ncnc5cnc(nc45)S(C)(=O)=O)cc3C)ccc12

InChI Key InChIKey=INTSFJBLPCJEES-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 637899   

LigandPNGBDBM637899(US11834453, Example 5)
Affinity DataIC50: 9.80nMAssay Description:This synthesized DNA fragment was subsequently cloned into the baculovirus transfer vector, pAcSG2, between the NcoI and NotI sites. The resulting pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Array Biopharma

US Patent
LigandPNGBDBM637899(US11834453, Example 5)
Affinity DataIC50: 10.9nMAssay Description:The kinases were incubated with 250 nM TK-substrate biotin (CisBio, part of cat #62TK0PEC) at 1 mM ATP along with test compounds in a buffer consisti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
Go to US Patent