BDBM637597 US20230382915, Example 31

SMILES Cn1cc(cn1)-n1cc(-c2cccc(NS(=O)(=O)c3cc(Cl)cc(CO)c3Cl)c2F)c2c(N)ncnc12

InChI Key InChIKey=VVOLQYDIEHHVJS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 637597   

TargeteIF-2-alpha kinase GCN2(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM637597(US20230382915, Example 31)
Affinity DataIC50: 100nMAssay Description:Activity of GCN2 kinase was determined using a TR-FRET kinase activity assay (e.g. Riddle et al. Analytical Biochemistry (2006) 356(1) 108-116). Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM637597(US20230382915, Example 31)
Affinity DataIC50: 100nMAssay Description:Activity of PERK kinase was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that continuously monitors the A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent