BDBM637590 US20230382915, Example 23::US20230382915, Example 26

SMILES Cc1c(CO)cc(Cl)cc1S(=O)(=O)Nc1cccc(-c2cn(C)c3ncnc(N)c23)c1F

InChI Key InChIKey=VLNPTZVAWZCTDH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 637590   

TargeteIF-2-alpha kinase GCN2(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM637590(US20230382915, Example 23 | US20230382915, Example...)
Affinity DataIC50: 300nMAssay Description:Activity of GCN2 kinase was determined using a TR-FRET kinase activity assay (e.g. Riddle et al. Analytical Biochemistry (2006) 356(1) 108-116). Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM637590(US20230382915, Example 23 | US20230382915, Example...)
Affinity DataIC50: 100nMAssay Description:Activity of PERK kinase was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that continuously monitors the A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM637590(US20230382915, Example 23 | US20230382915, Example...)
Affinity DataIC50: 100nMAssay Description:Activity of GCN2 kinase was determined using a TR-FRET kinase activity assay (e.g. Riddle et al. Analytical Biochemistry (2006) 356(1) 108-116). Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM637590(US20230382915, Example 23 | US20230382915, Example...)
Affinity DataIC50: 100nMAssay Description:Activity of PERK kinase was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that continuously monitors the A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent