BDBM637575 US20230382915, Example 8

SMILES Nc1ncnc2n(cc(-c3cccc(NS(=O)(=O)c4cc(Cl)cc(CO)c4Cl)c3F)c12)C1CC1

InChI Key InChIKey=OQEFAPYRYKAIKU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 637575   

TargeteIF-2-alpha kinase GCN2(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM637575(US20230382915, Example 8)
Affinity DataIC50: 100nMAssay Description:Activity of GCN2 kinase was determined using a TR-FRET kinase activity assay (e.g. Riddle et al. Analytical Biochemistry (2006) 356(1) 108-116). Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Deciphera Pharmaceuticals

US Patent
LigandPNGBDBM637575(US20230382915, Example 8)
Affinity DataIC50: 100nMAssay Description:Activity of PERK kinase was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that continuously monitors the A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent