BDBM637019 2-(4,4-difluoropiperidin-1-yl)-6-(1-(4-((2- hydroxyethyl)sulfonamido)-2-(6- azaspiro[2.5]octan-6-yl)phenyl)-1H-1,2,3- triazol-4-yl)pyrimidine-4-carboxylic acid::US20230382889, Compound 158

SMILES OCCS(=O)(=O)Nc1ccc(c(c1)N1CCCCC1)-n1cc(nn1)-c1cc(nc(n1)N1CCC(F)(F)CC1)C(O)=O

InChI Key InChIKey=MTCBZQNJESZJII-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 637019   

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM637019(US20230382889, Compound 158 | 2-(4,4-difluoropiper...)
Affinity DataIC50: 3.80nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
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