BDBM637005 3-(4,4-difluoropiperidin-1-yl)-5-(1-(4- (ethylsulfonamido)-2-(6- azaspiro[2.5]octan-6-yl)phenyl)-1H-1,2,3- triazol-4-yl)pyrazine 1-oxide::US20230382889, Compound 146

SMILES CCS(=O)(=O)Nc1ccc(c(c1)N1CCC2(CC2)CC1)-n1cc(nn1)-c1c[n+]([O-])cc(n1)N1CCC(F)(F)CC1

InChI Key InChIKey=HQOIUDUDHQJEQL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 637005   

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM637005(US20230382889, Compound 146 | 3-(4,4-difluoropiper...)
Affinity DataIC50: 4.40nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
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