BDBM637003 N-(4-(4-(6-(4,4-difluoropiperidin-1- yl)pyrazin-2-yl)-1H-1,2,3-triazol-1-yl)-2- fluoro-5-(6-azaspiro[2.5]octan-6- yl)phenyl)-2-hydroxyethane-1- sulfonamide::US20230382889, Compound 144

SMILES OCCS(=O)(=O)Nc1cc(N2CCC3(CC3)CC2)c(cc1F)-n1cc(nn1)-c1cncc(n1)N1CCC(F)(F)CC1

InChI Key InChIKey=MJQHIFNMJUCBSN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 637003   

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM637003(US20230382889, Compound 144 | N-(4-(4-(6-(4,4-difl...)
Affinity DataIC50: 2.80nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent