BDBM636941 N-(4-(4-(1-(4,4-difluorocyclohexyl)-1H- pyrazol-3-yl)-1H-1,2,3-triazol-1-yl)-3-(6- azaspiro[2.5]octan-6-yl)phenyl)-2- hydroxyethane-1-sulfonamide::US20230382889, Compound 130::US20230382889, Compound 84

SMILES OCCS(=O)(=O)Nc1ccc(c(c1)N1CCC2(CC2)CC1)-n1cc(nn1)-c1ccn(n1)C1CCC(F)(F)CC1

InChI Key InChIKey=LWRMKJICRMZNFM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 636941   

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM636941(US20230382889, Compound 84 | N-(4-(4-(1-(4,4-diflu...)
Affinity DataIC50: 8.20nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent

TargetKinesin-like protein KIF18A(Human)
Volastra Therapeutics

US Patent
LigandPNGBDBM636941(US20230382889, Compound 84 | N-(4-(4-(1-(4,4-diflu...)
Affinity DataIC50: 5nMAssay Description:Test compounds were plated in a 3x dilution scheme in a 384-well plate. Assay buffer: 80 mM PIPES (pH 6.9), 1 mM MgCl2, 75 mM KCl, 1 mM EGTA, 1 mM DT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2024
Entry Details
Go to US Patent