BDBM636040 (1R,2S)-2-[3-({2-[(3R)-3-fluoropyrrolidin-1-yl]-5-methoxypyrimidin-4-yl}amino)-1H-indazol-6-yl]-5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'H)-one::US20230365537, Example 169

SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(Nc5nc(ncc5OC)N5CC[C@@H](F)C5)n[nH]c4c3)c2c1

InChI Key InChIKey=DVCNPIFFEMVJNY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 636040   

TargetSerine/threonine-protein kinase PLK4(Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636040(US20230365537, Example 169 | (1R,2S)-2-[3-({2-[(3R...)
Affinity DataIC50: 0.995nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636040(US20230365537, Example 169 | (1R,2S)-2-[3-({2-[(3R...)
Affinity DataIC50: 664nMAssay Description:Activity of human recombinant Aurora A (ThermoFisher, cat #PR5935A) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM636040(US20230365537, Example 169 | (1R,2S)-2-[3-({2-[(3R...)
Affinity DataIC50: 429nMAssay Description:Activity of human recombinant Aurora B (ThermoFisher, cat #PR9210B) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
Go to US Patent