BDBM635959 (1R,2S)-2-(3-((6-(1,1-dioxidothiomorpholino)-2-isopropyl-5-methoxypyrimidin-4-yl)amino)-1H-indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one::US20230365537, Example 84

SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(Nc5nc(nc6N7CCS(=O)(=O)CC7COc56)C(C)C)n[nH]c4c3)c2c1

InChI Key InChIKey=TXKJMMAMZNSOJM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 635959   

TargetSerine/threonine-protein kinase PLK4(Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635959(US20230365537, Example 84 | (1R,2S)-2-(3-((6-(1,1-...)
Affinity DataIC50: 1.28nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635959(US20230365537, Example 84 | (1R,2S)-2-(3-((6-(1,1-...)
Affinity DataIC50: 5.00E+4nMAssay Description:Activity of human recombinant Aurora A (ThermoFisher, cat #PR5935A) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635959(US20230365537, Example 84 | (1R,2S)-2-(3-((6-(1,1-...)
Affinity DataIC50: 4.03E+3nMAssay Description:Activity of human recombinant Aurora B (ThermoFisher, cat #PR9210B) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
Go to US Patent