BDBM635930 (1R,2S)-2-(3-{[5-(2-hydroxyethyl)-3-methoxypyrazin-2-yl]amino}-1H-indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'H)-one::US20230365537, Example 55

SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(Nc5ncc(CCO)nc5OC)n[nH]c4c3)c2c1

InChI Key InChIKey=IVVSNTYYOLGITN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 635930   

TargetSerine/threonine-protein kinase PLK4(Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635930(US20230365537, Example 55 | (1R,2S)-2-(3-{[5-(2-hy...)
Affinity DataIC50: 1.25nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635930(US20230365537, Example 55 | (1R,2S)-2-(3-{[5-(2-hy...)
Affinity DataIC50: 4.06E+3nMAssay Description:Activity of human recombinant Aurora A (ThermoFisher, cat #PR5935A) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Oric Pharmaceuticals

US Patent
LigandPNGBDBM635930(US20230365537, Example 55 | (1R,2S)-2-(3-{[5-(2-hy...)
Affinity DataIC50: 22nMAssay Description:Activity of human recombinant Aurora B (ThermoFisher, cat #PR9210B) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
Go to US Patent