BDBM635743 US20230364079, Example 152

SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(F)(F)c3cccc(Cl)c3F)c12)C12CCC(CO)(CC1)OC2

InChI Key InChIKey=ZRNZTAHFNDWRTI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 635743   

TargetTyrosine-protein kinase BTK(Human)
Chengdu Hyperway Pharmaceuticals

US Patent
LigandPNGBDBM635743(US20230364079, Example 152)
Affinity DataIC50: 550nMAssay Description:Kinase Reaction Process: (1) Preparation of 1 × Kinase buffer.(2) Preparation of compound with gradient concentrations: The test compound was tested ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
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TargetReceptor tyrosine-protein kinase erbB-2(Human)
Chengdu Hyperway Pharmaceuticals

US Patent
LigandPNGBDBM635743(US20230364079, Example 152)
Affinity DataIC50: 4.19nMAssay Description:1) 1× kinase reaction buffer was prepared from 1 volume of 5× kinase reaction buffer and 4 volumes of water, 1 mM dithiothreitol, 5 mM magnesium chlo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
Go to US Patent