BDBM634588 US11814367, Compound 37::US11814367, Compound 38

SMILES CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccccn1)c1ccccc1

InChI Key InChIKey=WHAFIVQIADSJRF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 634588   

TargetGlycogen [starch] synthase, liver(Human)
Maze Therapeutics

US Patent
LigandPNGBDBM634588(US11814367, Compound 37 | US11814367, Compound 38)
Affinity DataIC50: 1.00E+5nMAssay Description:Compounds that inhibit the hGYS2 enzyme and, subsequently, the downstream conversion of NADH to NAD+, were tested using assay ready plates (black, cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
Go to US Patent

TargetGlycogen [starch] synthase, liver(Human)
Maze Therapeutics

US Patent
LigandPNGBDBM634588(US11814367, Compound 37 | US11814367, Compound 38)
Affinity DataIC50: 1.00E+5nMAssay Description:Compounds that inhibit the hGYS2 enzyme and, subsequently, the downstream conversion of NADH to NAD+, were tested using assay ready plates (black, cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
Go to US Patent

TargetGlycogen [starch] synthase, muscle(Human)
Maze Therapeutics

US Patent
LigandPNGBDBM634588(US11814367, Compound 37 | US11814367, Compound 38)
Affinity DataIC50: 45nMAssay Description:Compounds that inhibit the hGYS1 enzyme and, subsequently, the downstream conversion of NADH to NAD+, were tested using assay ready plates (black, cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
Go to US Patent

TargetGlycogen [starch] synthase, muscle(Human)
Maze Therapeutics

US Patent
LigandPNGBDBM634588(US11814367, Compound 37 | US11814367, Compound 38)
Affinity DataIC50: 51nMAssay Description:Compounds that inhibit the hGYS1 enzyme and, subsequently, the downstream conversion of NADH to NAD+, were tested using assay ready plates (black, cl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
Go to US Patent