BDBM634096 1-{(1 S,4S)-5-[4-({(1R)-1-[3-(1,1-difluoro-2-hydroxy-2-methylpropyl)-2-fluorophenyl]ethyl}amino)-2,7-dimethylpyrido[2,3-d]pyrimidin-6-yl]-2,5-diazabicyclo[2.2.1]heptan-2-yl}ethan-1-one::US20230357239, Example 64

SMILES C[C@@H](Nc1nc(C)nc2nc(C)c(N[C@H]3C[C@@H](C)N(C3)C(C)=O)cc12)c1cccc(c1F)C(F)(F)C(C)(C)O

InChI Key InChIKey=ZBKGXLMFYBJMQA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 634096   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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US Patent
LigandPNGBDBM634096(US20230357239, Example 64 | 1-{(1 S,4S)-5-[4-({(1R...)
Affinity DataIC50: 4.35nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
Entry Details
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