BDBM634094 1-{4-[4-({(1R)-1-[3-(1,1-difluoro-2-hydroxy-2-methylpropyl)-2-fluorophenyl]ethyl}amino)-2,7-dimethylpyrido[2,3-d]pyrimidin-6-yl]-5-methyl-3,6-dihydropyridin-1(2H)-yl}ethan-1-one::US20230357239, Example 62

SMILES C[C@@H](Nc1nc(C)nc2nc(C)c(cc12)C1=C(C)CN(CC1)C(C)=O)c1cccc(c1F)C(F)(F)C(C)(C)O

InChI Key InChIKey=BJJXELRQMQRJTC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 634094   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM634094(US20230357239, Example 62 | 1-{4-[4-({(1R)-1-[3-(1...)
Affinity DataIC50: 14.5nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
Entry Details
Go to US Patent