BDBM634086 1-{6-[4-({(1R)-1-[3-(1,1-difluoro-2-hydroxy-2-methylpropyl)-2-fluorophenyl]ethyl}amino)-2-methylpyrido[2,3-d]pyrimidin-6-yl]-2,6-diazaspiro[3.3]heptan-2-yl}ethan-1-one::US20230357239, Example 54

SMILES C[C@@H](Nc1nc(C)nc2ncc(cc12)N1CC2(CN(C2)C(C)=O)C1)c1cccc(c1F)C(F)(F)C(C)(C)O

InChI Key InChIKey=HIOQMYFUQLQNGY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 634086   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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US Patent
LigandPNGBDBM634086(US20230357239, Example 54 | 1-{6-[4-({(1R)-1-[3-(1...)
Affinity DataIC50: 3.52nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
Entry Details
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