BDBM634072 1-{3-[2-methyl-4-({(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl}amino)pyrido[2,3-d]pyrimidin-6-yl]azetidin-1-yl}ethan-1-one::US20230357239, Example 40

SMILES C[C@@H](Nc1nc(C)nc2ncc(cc12)C1CN(C1)C(C)=O)c1cccc(c1C)C(F)(F)F

InChI Key InChIKey=VNXXNKVDRXWCFM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 634072   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM634072(US20230357239, Example 40 | 1-{3-[2-methyl-4-({(1R...)
Affinity DataIC50: 16.1nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
Entry Details
Go to US Patent