BDBM634068 1-{4-[2-methyl-4-({(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl}amino)pyrido[2,3-d]pyrimidin-6-yl]-4-oxo-4lambda5-piperazin-1-yl}ethan-1-one::US20230357239, Example 36

SMILES C[C@@H](Nc1nc(C)nc2ncc(cc12)[NH+]1CCN(CC1)C(C)=O)c1cccc(c1C)C(F)(F)F

InChI Key InChIKey=GSLLDRRIFVILDW-UHFFFAOYSA-O

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 634068   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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US Patent
LigandPNGBDBM634068(US20230357239, Example 36 | 1-{4-[2-methyl-4-({(1R...)
Affinity DataIC50: 6.46nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
Entry Details
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