BDBM634046 1-{(1S,4S)-5-[2-methyl-4-({(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl}amino)pyrido[2,3-d]pyrimidin-6-yl]-2,5-diazabicyclo[2.2.1]heptan-2-yl}ethan-1-one::US20230357239, Example 14

SMILES C[C@@H](Nc1nc(C)nc2ncc(cc12)N1C[C@@H]2C[C@H]1CN2C(C)=O)c1cccc(c1C)C(F)(F)F

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 634046   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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US Patent
LigandPNGBDBM634046(US20230357239, Example 14 | 1-{(1S,4S)-5-[2-methyl...)
Affinity DataIC50: 5.15nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
Entry Details
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