BDBM634040 1-{6-[2-methyl-4-({(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl}amino)pyrido[2,3-d]pyrimidin-6-yl]-2,6-diazaspiro[3.3]heptan-2-yl}ethan-1-one::US20230357239, Example 13::US20230357239, Example 8

SMILES C[C@@H](Nc1nc(C)nc2ncc(cc12)N1CC2(CN(C2)C(C)=O)C1)c1cccc(c1C)C(F)(F)F

InChI Key InChIKey=IXJBXZMXCFSVFO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 634040   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM634040(US20230357239, Example 8 | 1-{6-[2-methyl-4-({(1R)...)
Affinity DataIC50: 15.7nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
Entry Details
Go to US Patent

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM634040(US20230357239, Example 8 | 1-{6-[2-methyl-4-({(1R)...)
Affinity DataIC50: 6.35nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2024
Entry Details
Go to US Patent