BDBM634035 6-(4-methylpiperazin-1-yl)—N-{(1R)-1-[3-(trifluoromethyl)phenyl]ethyl}pyrido[2,3-d]pyrimidin-4-amine::US20230357239, Example 3

SMILES C[C@@H](Nc1ncnc2ncc(cc12)N1CCN(C)CC1)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=JWEBWBLMPOIYDM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 634035   

TargetSon of sevenless homolog 1/GTPase KRas [G12C](Human)
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US Patent
LigandPNGBDBM634035(US20230357239, Example 3 | 6-(4-methylpiperazin-1-...)
Affinity DataIC50: 13.9nMAssay Description:The assay buffer containes 5 mM HEPES pH 7.4 (Applichem), 150 mM NaCl (Sigma), 10 mM EDTA (Promega), 1 mM DTT (Thermofisher), 0.05% BSA Fraction V, p...More data for this Ligand-Target Pair
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Date in BDB:
1/4/2024
Entry Details
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