BDBM633479 N-(3-fluoro-4-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)phenyl)sulfamide hydrochloride::US20230159469, Example 189

SMILES NS(=O)(=O)Nc1ccc(Cc2n[nH]c(=O)c3ccccc23)c(F)c1

InChI Key InChIKey=RSWDFPHBMQXSLN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 633479   

LigandPNGBDBM633479(N-(3-fluoro-4-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataIC50: 1.00E+3nMAssay Description:ENPP1 hydrolyzes nucleotides or nucleotide derivatives to produce nucleoside -5′-monophosphate and pyrophosphate. in addition, ENPP1 hydrolyzes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
Go to US Patent

LigandPNGBDBM633479(N-(3-fluoro-4-((4-oxo-3,4-dihydrophthalazin-1-yl)m...)
Affinity DataIC50: 273nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed