BDBM633478 5-((6,7-dimethoxy-3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)methyl)indoline-1-sulfonamide hydrochloride::US20230159469, Example 188

SMILES COc1cc2c(Cc3ccc4N(CCc4c3)S(N)(=O)=O)nn(C)c(=O)c2cc1OC

InChI Key InChIKey=HWWUJTXMBFGUFI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 633478   

LigandPNGBDBM633478(5-((6,7-dimethoxy-3-methyl-4-oxo-3,4-dihydrophthal...)
Affinity DataIC50: 1.00E+3nMAssay Description:ENPP1 hydrolyzes nucleotides or nucleotide derivatives to produce nucleoside -5′-monophosphate and pyrophosphate. in addition, ENPP1 hydrolyzes...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
Go to US Patent

LigandPNGBDBM633478(5-((6,7-dimethoxy-3-methyl-4-oxo-3,4-dihydrophthal...)
Affinity DataIC50: 207nMAssay Description:Inhibition of recombinant human ENPP1 using cGAMP as substrate assessed as inhibition of cGAMP hydrolysis preincubated for 5 to 10 mins followed by s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed