BDBM633349 US20190276450, Example 22.2

SMILES CO[C@]1(CCOC1)c1cc(OC(F)F)cc(n1)-c1cn(C)c2cnc(NC(C)=O)cc12

InChI Key InChIKey=GXVAJXOVPCLSSK-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 633349   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Abbvie

US Patent
LigandPNGBDBM633349(US20190276450, Example 22.2)
Affinity DataEC50:  89nMAssay Description:IL-12 is known to transduce its signal through IL-12 receptor via Jak2 and/or Tyk2. For that reason, the activity against Tyk2/Jak2 was measured by d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Abbvie

US Patent
LigandPNGBDBM633349(US20190276450, Example 22.2)
Affinity DataEC50:  3.50E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633349(US20190276450, Example 22.2)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Abbvie

US Patent
LigandPNGBDBM633349(US20190276450, Example 22.2)
Affinity DataEC50:  90nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed