BDBM633291 US20190276450, Example 4

SMILES COCc1cc(nc(c1)[C@@]1(CCOC1)OC)-c1cn(C2COC2)c2cnc(NC(C)=O)cc12

InChI Key InChIKey=GTXKSTKFOCDTPI-UHFFFAOYSA-N

Data  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 633291   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Abbvie

US Patent
LigandPNGBDBM633291(US20190276450, Example 4)
Affinity DataEC50:  137nMAssay Description:IL-12 is known to transduce its signal through IL-12 receptor via Jak2 and/or Tyk2. For that reason, the activity against Tyk2/Jak2 was measured by d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Abbvie

US Patent
LigandPNGBDBM633291(US20190276450, Example 4)
Affinity DataEC50: >1.00E+5nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633291(US20190276450, Example 4)
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2023
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Abbvie

US Patent
LigandPNGBDBM633291(US20190276450, Example 4)
Affinity DataEC50:  195nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Abbvie

US Patent
LigandPNGBDBM633291(US20190276450, Example 4)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of JAK1 in human TF-1 cells assessed as reduction in IL-6 induced STAT3 phosphorylation at Tyr705 residue preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Abbvie

US Patent
LigandPNGBDBM633291(US20190276450, Example 4)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of JAK2 in human UT7 cells assessed as reduction in erythropoietin induced STAT5 phosphorylation preincubated for 30 mins followed by eryt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM633291(US20190276450, Example 4)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of JAK3 in human T-blast cells assessed as reduction in IL-2 induced STAT5 phosphorylation preincubated for 30 mins followed by IL-2 stimu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Abbvie

US Patent
LigandPNGBDBM633291(US20190276450, Example 4)
Affinity DataEC50:  160nMAssay Description:Inhibition of TYK2 in human whole blood assessed as decrease in STAT4 phosphorylation preincubated for 30 mins followed by human IL-23 stimulation an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633291(US20190276450, Example 4)
Affinity DataEC50:  1.40E+3nMAssay Description:Inhibition of TYK2 in C57/B6 mouse whole blood assessed as decrease in STAT4 phosphorylation preincubated for 30 mins followed by mouse IL-12p70 stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed