BDBM633221 US20230348487, Example LS 6-89

SMILES CCN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(O[C@@H]3CO[C@@H]4[C@H](F)CO[C@H]34)n2)cc1NC(=O)C=C

InChI Key InChIKey=REANPTQOSCBIQC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 633221   

TargetTyrosine-protein kinase JAK1(Human)
Guangzhou Salustier Biosciences

US Patent
LigandPNGBDBM633221(US20230348487, Example LS 6-89)
Affinity DataIC50: 1.56E+4nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Guangzhou Salustier Biosciences

US Patent
LigandPNGBDBM633221(US20230348487, Example LS 6-89)
Affinity DataIC50: 1.71E+3nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Guangzhou Salustier Biosciences

US Patent
LigandPNGBDBM633221(US20230348487, Example LS 6-89)
Affinity DataIC50: 4.26nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Guangzhou Salustier Biosciences

US Patent
LigandPNGBDBM633221(US20230348487, Example LS 6-89)
Affinity DataIC50: 805nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Guangzhou Salustier Biosciences

US Patent
LigandPNGBDBM633221(US20230348487, Example LS 6-89)
Affinity DataIC50: 6.54nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent