BDBM631219 US11802133, Example 75

SMILES FC(F)(F)c1ccc(COC2CN(C2)C(=O)N2CC[C@@H]3OCC(=O)N[C@@H]3C2)c(Cl)c1

InChI Key InChIKey=RNRJERHACBDJTL-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 631219   

TargetMonoglyceride lipase(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM631219(US11802133, Example 75)
Affinity DataIC50: 2nMAssay Description:The 4-NPA assay was carried out in 384 well assay plates (black with clear bottom, non-binding surface treated, Corning Ref. 3655) in a total volume ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Mouse)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM631219(US11802133, Example 75)
Affinity DataKd:  5.70nMAssay Description:Binding affinity to full-length mouse N-terminal His6-tagged TEV-MAGL assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
Eth Zurich

Curated by ChEMBL
LigandPNGBDBM631219(US11802133, Example 75)
Affinity DataIC50: 19nMAssay Description:Inhibition of mouse MAGL pretreated for 15 mins followed by 2-AG addition and measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed